Synthesis of γ-Aminophosphonates via Photocatalytic Radical Relay Process

Organic Letters 2026

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Authors: Kui Zhang, Yang Chen, Xueping Zhang, Lingchao Cai
DOI: 10.1021/acs.orglett.5c04947
Cited by: 1
References: 45

Abstract

γ-Aminophosphonates exhibit promising biological activities and medicinal potential, yet efficient synthetic methods for their preparation remain limited. Herein, we develop a mild and efficient photocatalytic strategy for the construction of γ-aminophosphonates via an aryl radical-initiated radical relay process, using easily synthesizable oxime esters as precursors for both phenyl radicals and iminyl radicals. This method features a broad substrate scope and excellent functional group tolerance. Additionally, the products can be further transformed into complex azaphosphorus heterocycles.

Fields of Study & Subjects

Organophosphorus compounds synthesis Radical Photochemical Reactions Sulfur-Based Synthesis Techniques

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
2
Pages
774–781
Publication date
5 January 2026
Language
EN