Direct Indazole Synthesis via Ruthenium(II)-Catalyzed Acceptorless Dehydrogenative Annulation of Alcohols and Arylhydrazines

Organic Letters 2026

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Authors: Yinyin Chen, Hua Chen, Xueli Zheng, Weichao Xue, Haiyan Fu, Ruixiang Li
DOI: 10.1021/acs.orglett.5c04970
Cited by: 1
References: 39

Abstract

Indazole serves as an important organic synthetic intermediate with significant pharmaceutical activity. Herein, we report the first example of efficiently constructing the indazole framework through an acceptorless dehydrogenative annulation reaction using alcohols and hydrazines as starting materials. This strategy, which employs an N -heterocyclic carbene ( NHC )-imine-phosphine ( CNP ) pincer ruthenium catalyst, operates under mild conditions with high efficiency, offering a new pathway to simplify indazole synthesis.

Fields of Study & Subjects

Asymmetric Hydrogenation and Catalysis Catalytic C–H Functionalization Methods N-Heterocyclic Carbenes in Organic and Inorganic Chemistry

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
2
Pages
819–824
Publication date
2 January 2026
Language
EN