A Polarity-Mismatched Photocatalytic Cross-Coupling Enables Diversity-Oriented Synthesis of aza-Heterocycles

Organic Letters 2026 Open access

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Authors: Joanna Urbańczyk, Aidan P. McKay, David B. Cordes, Tomáš Lébl, Miles H. Aukland, Allan J. B. Watson
DOI: 10.1021/acs.orglett.5c04971
Cited by: 0
References: 23

Abstract

Diversity-oriented synthesis (DOS) is an attractive approach for the design of functional molecules with (homo)allylic amines representing a particularly attractive DOS platform. Herein, we demonstrate the application of newly developed photocatalytic cross-nucleophilic coupling to provide rapid access to (homo)allylic amines, which can be smoothly converted to a range of heterocyclic scaffolds. Employing this approach, a variety of aza-heterocycles were accessed, including α-haloaziridines, pyrrolidines, and oxazinan-2-ones, with structural diversity examined by using uniform manifold approximation and projection (UMAP).

Fields of Study & Subjects

Radical Photochemical Reactions Synthesis and Catalytic Reactions Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Organic Letters
Volume
28
Issue
6
Pages
1953–1957
Publication date
3 February 2026
Language
EN