Arylative Coupling of Pyridylphosphonium Salts with Aryl Thianthrenium Salts Enabled by Palladium Catalysis

Organic Letters 2026

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Authors: Shixin Zhuang, Lei Yu, Duo Zhang, Xiaowen Teng, Guodong Zhang
DOI: 10.1021/acs.orglett.5c04972
Cited by: 3
References: 59

Abstract

Thianthrenium and phosphonium salts, readily installed via C-H functionalization, serve as versatile handles for arene diversification. Herein, we report a palladium-catalyzed direct coupling between pyridylphosphonium salts and arylthianthrenium salts to access 4-arylpyridines. This strategy is notable for bypassing both preformed organometallics and stoichiometric silver activators. The protocol is streamlined and practical, exhibiting excellent functional group compatibility and thus holding significant potential for the late-stage diversification of complex molecules.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Advanced Synthetic Organic Chemistry

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
5
Pages
1586–1591
Publication date
21 January 2026
Language
EN