Asymmetric Synthesis of Axially Chiral Olefins and Heterobiaryls via Rhodium-Catalyzed C–C Activation and [4 + 2] Annulation
Abstract
Axially chiral biaryls are privileged scaffolds in chiral ligands, catalysts, and functional molecules. Reported herein is rhodium-catalyzed atroposelective [4 + 2] annulation of benzocyclobutenols with alkynes. The coupling system is chemodivergent under silver additive control as a result of controlled dehydration in post-annulation reactions, affording axially chiral heterobiaryls or olefins in excellent regio- and enantioselectivity.
Fields of Study & Subjects
Axial and Atropisomeric Chirality Synthesis
Catalytic C–H Functionalization Methods
Catalytic Alkyne Reactions
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 2
- Pages
- 825–830
- Publication date
- 2 January 2026
- Language
- EN