Rh-Catalyzed Asymmetric Hydrogenation of Polynitrogen Heterocycle-Substituted Phenylacrylonitriles

Organic Letters 2026

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Authors: Yu Zhu, Fang Xie, Fan Gao, Xiaoxue Wu, Zhanbin Zhang, Guohua Hou
DOI: 10.1021/acs.orglett.5c04978
Cited by: 3
References: 43

Abstract

A highly efficient enantioselective hydrogenation of polynitrogen heterocycle-substituted phenylacrylonitriles catalyzed by the Rh-f-spiroPhos complex has been developed. A series of chiral α- and β-polynitrogen heterocycle-substituted nitriles were obtained in high yields (up to 99%) with excellent enantioselectivities (up to 99.9% ee). This method provides an efficient straightforward approach for synthesis of chiral polynitrogen heterocycles, which is one of the most important and prevalent structures in pharmaceuticals and natural products.

Fields of Study & Subjects

Asymmetric Hydrogenation and Catalysis Surface Chemistry and Catalysis Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
5
Pages
1592–1597
Publication date
22 January 2026
Language
EN