Hunterlanines A–F, Neuroprotective Monoterpenoid Indole Alkaloid Heterodimers from Hunteria zeylanica
Abstract
Six novel monoterpenoid indole alkaloid (MIA) heterodimers, hunterlanines A–F ( 1 – 6 ), were isolated from Hunteria zeylanica . Compounds 1 and 2 possess unprecedented carbon skeletons featuring cage-like 6/5/6/6/6/5/6 heptacyclic and 6/5/6/6/6/6 hexacyclic cores, respectively. Compounds 3 and 4 represent the first MIA-phenylpropanoid heterodimers characterized by an unusual C–C and N–C connectivity, forming two different 6/5/5/8/6 pentacyclic scaffolds. Compounds 5 and 6 exemplify novel heterodimers in which the MIA moiety was coupled with indole derivative or indole via C–C linkages. Their structures were established by spectroscopic analyses, X-ray crystallography, and quantum chemical calculations. Notably, compounds 1, 4, and 6 exhibited significant neuroprotective activity against l -glutamate-induced neural injury in HT-22 cells.
Fields of Study & Subjects
Alkaloids: synthesis and pharmacology
Plant chemical constituents analysis
Berberine and alkaloids research
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 3
- Pages
- 1008–1014
- Publication date
- 8 January 2026
- Language
- EN