Total Synthesis of Lucidimines/Ganocalicines A/B, Sinensine E, and Ganocochlearine E

Organic Letters 2026

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Authors: Guddeti Sai, Chepuri Venkata Ramana
DOI: 10.1021/acs.orglett.5c04999
Cited by: 0
References: 56

Abstract

The central tetracyclic framework shared by the Ganoderma alkaloids─lucidimines/ganocaclicines A and B, sinensine E, and ganocochlearine E─appears inherently predisposed to arise from a diyne-nitrile cyclotrimerization event. A Co(I)-catalyzed intramolecular [2 + 2 + 2]-alkynenitrile cyclotrimerization has been employed to accomplish the first racemic and enantioselective total syntheses of sinensine E, lucidimine A, and ganocochlearine E, thereby establishing/revising their assigned stereochemical structures.

Fields of Study & Subjects

Advanced Synthetic Organic Chemistry Catalytic Alkyne Reactions Chemical synthesis and alkaloids

Publication details

Journal / source
Organic Letters
Volume
28
Issue
4
Pages
1241–1246
Publication date
19 January 2026
Language
EN