Regio- and Stereoselective Synthesis of Polysubstituted γ-Lactams Enabled by Photocatalyzed Sequential Radical Aminoalkylation of MBH Acetates
Abstract
A visible-light photocatalytic method is reported for the regio- and stereoselective synthesis of polysubstituted γ-lactams from N -arylglycines and Morita–Baylis–Hillman (MBH) acetates. The reaction proceeds through sequential radical aminoalkylation of the dual electrophilic MBH acetate by photogenerated α-aminoalkyl radicals, forming a key γ,γ’-diaminobutyl ester intermediate that undergoes regioselective lactamization. This strategy provides a mild and efficient route to privileged γ-lactam scaffolds, demonstrating the rational integration of two versatile synthons in cascade reactions.
Fields of Study & Subjects
Radical Photochemical Reactions
Chemical Synthesis and Analysis
Asymmetric Synthesis and Catalysis
Publication details
- Journal / source
- Organic Letters
- Volume
- 28
- Issue
- 7
- Pages
- 2224–2229
- Publication date
- 9 February 2026
- Language
- EN