Uranyl-Enabled Photocatalytic C(sp 3 )–H Functionalization with Azoles

Organic Letters 2026

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Authors: Y Z Luo, Shu-Yun Zhang, Yan-Xin Jiang, Songbai Tang, Jia-Hao Ruan, Jing Su
DOI: 10.1021/acs.orglett.5c05026
Cited by: 1
References: 55

Abstract

Under mild conditions, uranyl nitrate catalyzed C(sp 3 )–center/azole coupling without external additives, offering a broad substrate scope and high yields (up to 95%). The method was further validated under sunlight and in scale-up experiments, highlighting its industrial potential. Experimental and theoretical studies show that uranyl nitrate acts via both hydrogen-atom transfer (HAT) and non-HAT concerted proton-electron transfer mechanisms. This approach provides a green, efficient protocol for C(sp 3 )–azole bond formation.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Radical Photochemical Reactions Asymmetric Hydrogenation and Catalysis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
6
Pages
1958–1963
Publication date
30 January 2026
Language
EN