Electrochemical or Photoredox Activation of Latent Electrophiles: Three-Component Mumm Rearrangement Cascade Reactions from Alkoxyamines

Organic Letters 2026 Open access

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Authors: Tan N. Huynh, Philip L. Norcott, Michelle L. Coote, Alex C. Bissember
DOI: 10.1021/acs.orglett.5c05049
Cited by: 4
References: 29

Abstract

This report exploits either electrochemical or photoredox triggers to promote the oxidative mesolytic cleavage of alkoxyamines to establish multicomponent Mumm rearrangement cascade reactions for the synthesis of imides and imidates. Readily accessible, bench-, air-, and moisture-stable alkoxyamines derived from 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) serve as masked carbocations in this approach.

Fields of Study & Subjects

Radical Photochemical Reactions Advanced Synthetic Organic Chemistry Synthesis and Catalytic Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
3
Pages
1019–1024
Publication date
8 January 2026
Language
EN