Bromination Functionalization of Diazo Compounds with CBr 4 via Convergent Paired Electrolysis

Organic Letters 2026 Open access

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Authors: Qi Wang, Wentian Wu, Haibo Mei, Jorge Escorihuela, Romana Pajkert, Gerd-Volker Röschenthaler, Jianlin Han
DOI: 10.1021/acs.orglett.5c05051
Cited by: 6
References: 33

Abstract

An electrochemical bromination of diazo compounds with CBr 4 as a bromine source via convergent paired electrolysis has been developed, which affords α-bromo phosphonates as products in up to 96% yields. This work represents the first example of direct anodic oxidation of diazos to couple with an in situ -generated nucleophile from the cationic reduction of CBr 4 by using CH 2 Cl 2 as a hydrogen source. This reaction features mild conditions, good substrate compatibility, and scale-up applicability, which represents a new electrochemical reaction mode of diazo compounds and also provides easy access to α-bromo phosphonates.

Fields of Study & Subjects

Vanadium and Halogenation Chemistry Environmental remediation with nanomaterials Cyclopropane Reaction Mechanisms

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
3
Pages
1025–1030
Publication date
13 January 2026
Language
EN