Direct Difunctionalization of Unsaturated Peptides: A Strategy for Concurrent Incorporation of Trifluoromethyl and Alkynyl Groups
Abstract
The simultaneous incorporation of alkyne and trifluoromethyl groups into peptides enables rapid access to multifunctional peptide structures. Herein, we report the first metal-free trifluoromethylalkynylation of unsaturated amino acids and peptides using a cheap trifluoromethylation reagent under mild conditions, offering a practical and versatile route to valuable scaffolds.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Chemical Synthesis and Analysis
Synthesis and Characterization of Pyrroles
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 5
- Pages
- 1667–1672
- Publication date
- 21 January 2026
- Language
- EN