N═N Coupling and Rearrangement of Arylamines with N-Nitrosoaromatics: Synthesis of Unsymmetric Azobenzenes

Organic Letters 2026

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Authors: Weijie Ren, Wanyue Yu, Xiangrong Xiao, Jiaqi Li, Siqing Liu, Jiehao Chen, Xiuwen Chen, Zhongzhi Zhu
DOI: 10.1021/acs.orglett.5c05130
Cited by: 2
References: 41

Abstract

This paper presents an efficient strategy for constructing unsymmetric azobenzenes through a cascade reaction between arylamines and N -nitrosoaromatics. This process proceeds via initial N═N bond formation, followed by N–N bond cleavage and concomitant C–N bond formation. The method employs stable and readily available arylamines and N-nitrosoaromatics as starting materials, producing water as the sole byproduct. Additional advantages include mild reaction conditions, high atom economy, operational simplicity, and broad substrate scope with excellent functional group tolerance.

Fields of Study & Subjects

Catalytic Cross-Coupling Reactions Nanomaterials for catalytic reactions Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
4
Pages
1295–1299
Publication date
17 January 2026
Language
EN