Visible-Light-Enabled Fluorosulfonylalkynylation of Alkenes

Organic Letters 2026

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Authors: Yucai Tang, Qiangsheng He, Jiale Liu, Jiaming Huang, Yonghao Li, Yao-Dan Xu, Jun-Ji Lu, Hai‐Tao Zhu, Wei‐Min He
DOI: 10.1021/acs.orglett.5c05131
Cited by: 1
References: 41

Abstract

A visible-light-enabled fluorosulfonylalkynylation of alkenes has been developed using alkynyl sulfonyl fluorides as bifunctional reagents under catalytic aryl diazonium activation. This photocatalyst- and oxidant-free protocol affords diverse 1-sulfonyl fluoride-2-alkynyl adducts in good yields with excellent chemoselectivity and a broad scope, enabling late-stage diversification while installing a SuFEx-ready sulfonyl fluoride and a versatile alkyne in one step.

Fields of Study & Subjects

Click Chemistry and Applications Fluorine in Organic Chemistry Radical Photochemical Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
3
Pages
1042–1047
Publication date
13 January 2026
Language
EN