Halide-Mediated Electrochemical Peptide Synthesis Applicable to Highly Sterically Hindered Amino Acids
Abstract
Abstract Electrochemical peptide synthesis using triaryl phosphines has been shown to be a promising approach for reducing the amount of waste in peptide synthesis. However, there is room for improvement from the viewpoint of the substrate scope. In this research, we succeeded in improving the reaction efficiency by utilizing a halide mediator. This method is applicable to highly sterically hindered amino acids, such as N-methyl phenylalanine. We also achieved the synthesis of icatibant, consisting of 10 amino acid residues.
Fields of Study & Subjects
Radical Photochemical Reactions
Chemical Synthesis and Analysis
Click Chemistry and Applications
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 21
- Pages
- 6497–6502
- Publication date
- 5 February 2026
- Language
- EN