Tetrazole Synthesis via Cyclopropenium Phase-Transfer Catalysis: A Click Strategy
Abstract
Morden organic synthesis prizes efficiency, robustness, and generality─hallmarks of click chemistry. Here, we introduce a metal-free catalytic method for synthesizing diverse tetrazole heterocycles from simple, shelf-stable precursors. Central to this powerful strategy is leveraging cyclopropenium ions as phase-transfer catalysts, providing a practical and efficient approach to tetrazoles from nitriles and azides. The scope, mechanism, and synthetic utility of this methodology are detailed, highlighting its potential to expand the click chemistry tool box for heterocycle synthesis.
Fields of Study & Subjects
Synthesis of Tetrazole Derivatives
Click Chemistry and Applications
Multicomponent Synthesis of Heterocycles
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 6
- Pages
- 1983–1988
- Publication date
- 30 January 2026
- Language
- EN