Methylalkylation of Unactivated Alkenes by Photoredox/Nickel Catalytic HAT and Radical Selectivity Control
Abstract
Herein, we report a strategy for the methylalkylation of unactivated alkenes via synergistic photoredox/nickel catalysis. This mild transformation employs di- tert -butyl peroxide (DTBP) as a bifunctional reagent, which serves simultaneously as a hydrogen atom transfer (HAT) reagent and a source of methyl radical, thereby facilitating the coupling of malonate-derived radicals with alkenes. By integrating HAT with radical selectivity control, the method enables the formation of two C(sp 3 )–C(sp 3 ) bonds in a single synthetic operation, offering a streamlined route to valuable three-dimensional scaffolds.
Fields of Study & Subjects
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 7
- Pages
- 2254–2259
- Publication date
- 5 February 2026
- Language
- EN