Total Synthesis of Chondrochloren A

Organic Letters 2026

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Authors: Koshik Das, Atulkumar S. Kedar, Subhash Ghosh
DOI: 10.1021/acs.orglett.5c05169
Cited by: 1
References: 37

Abstract

An asymmetric total synthesis of chondrochloren A, a polyketide-derived antibiotic characterized by an unusual Z -enamide attached to a chloro-hydroxy-styryl moiety and a densely oxygenated central segment, is described. A Paterson aldol reaction on an aldehyde generated from d -glucose provided a key amide fragment. Subsequent coupling of this intermediate with a Z -vinyl iodide, followed by protecting group removal, furnished the fully assembled natural product.

Fields of Study & Subjects

Synthetic Organic Chemistry Methods Plant-derived Lignans Synthesis and Bioactivity Asymmetric Synthesis and Catalysis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
4
Pages
1350–1354
Publication date
19 January 2026
Language
EN