A Multicatalytic Cascade for the Stereoselective Synthesis of 1,4-Chiral Nitro Alcohols

Organic Letters 2026 Open access

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Authors: Christian Ascaso-Alegre, Álvaro Linacero-Gracia, Patrícia Ferreira, Raquel P. Herrera, Juan Mangas-Sánchez
DOI: 10.1021/acs.orglett.5c05184
Cited by: 1
References: 26

Abstract

Artificial cascades offer a powerful strategy to access high-value chemicals efficiently. Here, we report the integration of metal catalysis, organocatalysis, and biocatalysis in a one-pot stereodivergent process to synthesize chiral 1,4-nitro alcohols bearing two stereocenters. Optimization of each step enabled the efficient and selective formation of all four diastereomers with excellent stereoselectivity (up to 97:3 dr and er) and good yields. This work highlights the potential of multicatalytic cascades for the synthesis of stereochemically rich molecules.

Fields of Study & Subjects

Asymmetric Hydrogenation and Catalysis Asymmetric Synthesis and Catalysis Chemical Synthesis and Analysis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
2
Pages
879–883
Publication date
2 January 2026
Language
EN