Helical Aromatic Oligoamide Macrocycle Incorporated with a Ferrocene Unit for Encapsulation and Chirality Signaling of Zwitterionic Proline

Organic Letters 2026

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Authors: Zejiang Liu, Maoxia Yang, Brice Kauffmann, Juting Tan, Yimin Cai, Cheng Yang, Xiaowei Li, Wen Feng, Ivan Huc, Lihua Yuan
DOI: 10.1021/acs.orglett.5c05193
Cited by: 5
References: 36

Abstract

A strategy for developing ferrocene-incorporated heteroditopic macrocycles for the recognition of zwitterionic proline is presented. The receptor features a well-defined helical cavity, and diastereomeric conformers result upon encapsulation of d/l-proline as indicated by X-ray crystallography. Incorporation of a ferrocene unit allows efficient chirality signaling, which is clearly manifested by circular dichroism and NMR spectroscopy upon guest binding. This work demonstrates a viable approach for constructing ditopic hydrogen-bonded aromatic oligoamide macrocycles capable of sensing zwitterionic amino acids.

Fields of Study & Subjects

Supramolecular Self-Assembly in Materials Molecular Sensors and Ion Detection Supramolecular Chemistry and Complexes

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
5
Pages
1703–1708
Publication date
26 January 2026
Language
EN