Catalytic Selective 1,2-Reduction of Quinolines by Dinuclear Rare Earth Metal Alkyl Complexes
Abstract
The reactions of RE(CH 2 SiMe 3 ) 3 (THF) 2 with N, N -dimethylethyl-functionalized 5,6,7,8-tetrahydroquinolin-8-amino ligand 1 afforded a series of dinuclear rare earth metal alkyl complexes 2a – 2d bearing a dianionic 5,6,7,8-tetrahydroquinolin-8-amido ligand through deprotonation and C–H bond activation processes. These dinuclear rare earth metal alkyl complexes efficiently catalyzed the selective 1,2-reduction of quinolines with ammonia borane (H 3 N·BH 3 ) to give the corresponding 1,2-dihydroquinolines in high yields, which provided a mild and efficient approach for the synthesis of 1,2-dihydroquinolines with broad functional group compatibility.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Organoboron and organosilicon chemistry
Asymmetric Hydrogenation and Catalysis
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 5
- Pages
- 1684–1689
- Publication date
- 22 January 2026
- Language
- EN