Cobaloxime-Catalyzed Radical C-Allyl Glycoside Assembly
Abstract
A direct allylic C–H glycosylation reaction is described, which involves the synergistic merger of photoredox-halogen atom transfer (XAT)/cobalt catalysis. This reaction enhances the application of Giese addition in the synthesis of C -alkyl glycosides by Co II capturing the alkyl radical intermediate/β-hydrogen abstraction to deliver highly valuable allyl glycosylation products. Moreover, the compatibility with the late-stage functionalization of pharmaceutical molecules and the potential for scalable production underscore the practical utility of this protocol in synthetic applications.
Fields of Study & Subjects
Radical Photochemical Reactions
Carbohydrate Chemistry and Synthesis
Cyclopropane Reaction Mechanisms
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 6
- Pages
- 2006–2011
- Publication date
- 29 January 2026
- Language
- EN