Direct Ether Synthesis Utilizing the Carbonyl Umpolung Reaction

Organic Letters 2026

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Authors: Isao Mizota, Miyuki Hotta, Ayaki Yamamoto, Maika Yasue, Junya Kobayashi, Rabbia Batool, Panneerselvam Sathishkumar, Makoto Shimizu
DOI: 10.1021/acs.orglett.5c05261
Cited by: 0
References: 39

Abstract

A direct ether synthesis was achieved by treating an α-ketoamide with a Grignard reagent, providing a simple one-step procedure compared with that of conventional ether-forming methods. This carbonyl umpolung-based O -alkylation proceeds smoothly to afford α-alkoxyamides in good yields. Furthermore, a tandem O -alkylation/aldol reaction with aldehydes was also developed to afford the desired aldol products with high diastereoselectivity.

Fields of Study & Subjects

Asymmetric Synthesis and Catalysis Advanced Synthetic Organic Chemistry Organic Chemistry Synthesis Methods

Publication details

Journal / source
Organic Letters
Volume
28
Issue
4
Pages
1407–1411
Publication date
19 January 2026
Language
EN