Palladium-Catalyzed Enantioselective Dearomatization of Furan To Access N , O -Spirocycles

Organic Letters 2026

View at publisher
Authors: Xinyue Wang, Chun Ma, Junfeng Yang, Junliang Zhang
DOI: 10.1021/acs.orglett.5c05263
Cited by: 3
References: 63

Abstract

N, O -Spirocycles are important structural motifs in efficient chiral ligands, natural products, and pharmaceuticals. However, the achievement of highly enantioselective N, O -spirocycles remains a challenge. Herein, we present a Pd-catalyzed enantioselective dearomatization of bromofurans with N -tosylhydrazones using a newly developed chiral sulfinamide phosphine ligand. The reaction features an excellent Z/E ratio, high enantioselectivity, and mild reaction conditions. The synthetic versatility of N, O -spirocycles is demonstrated.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Cyclopropane Reaction Mechanisms Catalytic Alkyne Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
5
Pages
1744–1749
Publication date
28 January 2026
Language
EN