Phosphonium Ylide-Catalyzed Z -Stereoselective Synthesis of α-Substituted Monofluoroalkenes from gem -Difluoroalkenes and Triazoles
Abstract
-difluoroalkenes and triazoles. The reaction is promoted with high stereoselectivity and compatible with a broad range of substrates. A wide range of complex natural products and pharmaceuticals are amenable to late-stage modification. Experimental mechanistic studies indicate that the phosphonium cation, formed via capture of the N-protecting group of triazole by the phosphine ylide, may play a key role in governing stereoselectivity.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Catalytic C–H Functionalization Methods
Click Chemistry and Applications
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 5
- Pages
- 1755–1760
- Publication date
- 22 January 2026
- Language
- EN