Photoinduced Amination of Inert C(sp 3 )–H Bonds with Diazirines for Access to Diaziridines
Abstract
)-H bonds is extremely attractive for constructing high-added-value molecules in synthetic chemistry. Herein, a metal-free and operationally simple method for the convenient synthesis of diaziridines is developed and affords moderate to good yields under mild reaction conditions. Various C-H precursors, including simple alkanes, free alcohols, esters, ethers, halides, nitriles, and heterocycles, were successfully utilized. Moreover, the synthesis of medicinally relevant heterocycles further highlights the synthetic potential of this strategy.
Fields of Study & Subjects
Synthesis and Catalytic Reactions
Catalytic C–H Functionalization Methods
Radical Photochemical Reactions
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 6
- Pages
- 2033–2037
- Publication date
- 29 January 2026
- Language
- EN