Collective Total Synthesis of (+)- and (−)-Baoslingzhines F–H, (+)- and (−)-Chizhiene C, and (+)- and (−)-Lingzhines E and F

Nityaprakash Patra; Akshaya S; Subhash Goshwami; Harsha Sankar S H; Ruthrotha Selvi Bharathavikru; Barla Thirupathi

doi:10.1021/acs.orglett.5c05297

Collective Total Synthesis of (+)- and (−)-Baoslingzhines F–H, (+)- and (−)-Chizhiene C, and (+)- and (−)-Lingzhines E and F

Organic Letters 2026

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Authors: Nityaprakash Patra, Akshaya S, Subhash Goshwami, Harsha Sankar S H, Ruthrotha Selvi Bharathavikru, Barla Thirupathi

DOI: 10.1021/acs.orglett.5c05297

Cited by: 0

References: 25

Abstract

We report a collective modular approach to the total syntheses of 12 naturally occurring diverse meroterpenoid natural products together with their enantiomers and diastereomeric congeners. The strategy centered on the efficient preparation of key intermediates, which enabled divergent synthetic routes by Michael addition with TBS-MAC, followed by meticulously designed deprotections and functional group manipulations. Our biological studies indicate a clear dependence of activity on absolute configuration, significantly enhancing the impact of the synthetic work.

Fields of Study & Subjects

Bioactive Natural Diterpenoids Research Magnolia and Illicium research Biological Activity of Diterpenoids and Biflavonoids

Publication details

Journal / source: Organic Letters
Volume: 28
Issue: 3
Pages: 1090–1094
Publication date: 7 January 2026
Language: EN

References 25