Ni-Catalyzed (A + 2B)-Type Reductive Coupling of Electron-Deficient Alkenes and Alkynes through a Selective Trimerization/1,6-Reduction Cascade

Organic Letters 2026

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Authors: Ming-Bai Gou, Deng-Yin Gou, Chun-Min Yang, Xing-Cui Wei, Bo Li, Jing Shi, Chong Zhao, Lei Tang, Rong-Hua Wang
DOI: 10.1021/acs.orglett.5c05300
Cited by: 1
References: 40

Abstract

The first nickel-catalyzed (A + 2B)-type reductive coupling of electron-deficient alkenes with alkynes has been developed. This method provides efficient access to diverse α-skipped dienyl esters in up to 99% yield with high chemo- and stereoselectivity. Synthetic utility is demonstrated in the late-stage modification of bioactive molecules and the development of antibacterial agents. Mechanistic studies indicate a stepwise pathway involving selective trimerization of alkenes with alkynes followed by a nickelacycle-mediated formal 1,6-reduction.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Radical Photochemical Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
5
Pages
1766–1771
Publication date
27 January 2026
Language
EN