Metabolic Competition between Non-reducing Polyketide Synthases Drives Hidden Chemodiversity in Deep-Sea Fungus Talaromyces radicus

Organic Letters 2026

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Authors: Jun Wu, Wenxing Chen, Bowei Wen, Jing Chen, Zhuoyue Yang, Lu Ke, Zhaoxin Yao, Zhicheng Guo, Hui Qiu, Zixin Deng, Ning Li, You‐Sheng Cai
+1 more Kui Hong
DOI: 10.1021/acs.orglett.5c05307
Cited by: 2
References: 26

Abstract

Genome mining of Talaromyces radicus WHUF04045 identified two unusual nrPKSs ( Tr4942 and Tr2381 ) with distinct release mechanisms, whose precursor competition was revealed by multiomics, gene deletion, and heterologous expression. Deletion of Tr4942 activated nine new chromone derivatives ( 1 – 9 ) and four new naphthoquinone derivatives ( 11 – 14 ), which displayed significant pro-angiogenic and anti-inflammatory activities, with compound 8 showing significant anti-inflammatory effects via modulation of the NF-κB signaling pathway.

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Microbial Metabolism and Applications Seaweed-derived Bioactive Compounds

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
10
Pages
3107–3111
Publication date
29 January 2026
Language
EN