Iron-Catalyzed Photoredox Decarboxylative Hydroalkylation with Alkynes and Alkenes
Abstract
A photocatalyzed decarboxylative hydroalkylation approach has been developed, providing efficient and stereoselective access to synthetically challenging Z -configured allylamine derivatives from carboxylic acids and alkynes. The reaction is mediated by an iron catalyst, offering a green, environmentally benign, and highly atom-economical process. Moreover, this protocol can be extended to the reaction with alkenes to furnish arylamines and aryl ethers. Overall, this strategy establishes a versatile synthetic platform for the functionalization of unsaturated hydrocarbons.
Fields of Study & Subjects
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Asymmetric Hydrogenation and Catalysis
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 7
- Pages
- 2338–2343
- Publication date
- 5 February 2026
- Language
- EN