Palladium-Catalyzed Intramolecular meta -C–H Arylation Assisted by Nitrile Templates Under Microwave-Accelerated Conditions Accessing Fluorene Frameworks
Abstract
Although intermolecular meta -C–H arylation has been thoroughly studied and well established, the intramolecular version of meta -C–H arylation is still largely unexplored and offers exciting opportunities for future research. With these considerations, we describe a palladium-catalyzed intramolecular meta -C–H arylation of 3-(4-benzylphenyl)propanoates, enabled by both aliphatic and aromatic nitrile templates under microwave-assisted conditions. This approach provides an efficient alternative pathway to fluorene frameworks via template-directed meta -C–H arylation. The method afforded fluorene derivatives exclusively in good to excellent yields. Additionally, postsynthetic modifications are used to access cyclopenta[ b ]fluorenones.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Radical Photochemical Reactions
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 10
- Pages
- 3112–3116
- Publication date
- 26 February 2026
- Language
- EN