Integration of Proximal Alkoxide and Lewis Acidic Cations To Boost Nickel-Catalyzed Borylation
Abstract
Nickel catalysis offers a sustainable alternative to palladium catalysis for cross-coupling reactions, yet ligands tailored for nickel catalysis are lacking. We introduce new phosphine ligands designed to facilitate the incorporation of Lewis acidic cations. The combination of a phosphinoalcohol ligand with either ( n -Bu) 2 Mg or KHMDS, as a source of Mg 2+ or K + cations respectively, proved to be optimal for the borylation of aryl chlorides. Studies verified that incorporation of Lewis acidic cations in the proximity of the Ni center enhances reactivity.
Fields of Study & Subjects
Catalytic Cross-Coupling Reactions
Catalytic C–H Functionalization Methods
Organoboron and organosilicon chemistry
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 4
- Pages
- 1436–1440
- Publication date
- 19 January 2026
- Language
- EN