N-Heterocyclic Carbene-Catalyzed Enantioselective Synthesis of Inherently Chiral Pillar[5]arenes

Organic Letters 2026

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Authors: Yinsheng Qi, Xuange Cui, Xiyu Li, Jianwei Cheng, Xin‐Ping Hui
DOI: 10.1021/acs.orglett.5c05330
Cited by: 3
References: 46

Abstract

Catalytic asymmetric synthesis of inherently chiral pillar[5]arene derivatives is promising in materials science, chemical biology, and host-guest chemistry due to their unique pillar structure. In this work, we developed an N-heterocyclic carbene-catalyzed asymmetric intermolecular esterification to construct homo- or heterorimmed inherently chiral pillar[5]arenes with moderate yields and high to excellent enantioselectivities (up to >99% ee). The experimental results showed that the inherently chiral pillar[5]arene diester was highly thermally stable.

Fields of Study & Subjects

N-Heterocyclic Carbenes in Organic and Inorganic Chemistry Supramolecular Chemistry and Complexes Synthesis and Properties of Aromatic Compounds

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
12
Pages
3671–3676
Publication date
16 March 2026
Language
EN