Photochemical Zincke-like Reactions Enabled the Expeditious Synthesis of 2-Polyene Sulfonylpyridines

Organic Letters 2026

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Authors: Min Shen, Nianhua Luo, Guodong Zhu, Zhi-Yang Zhou, Cheng Fu, Xin-Yun Zhong, Huang He-bin, Xiangjun Peng
DOI: 10.1021/acs.orglett.5c05332
Cited by: 0
References: 42

Abstract

A Ce-base-controlled and visible-light-induced approach enables the cleavage of NTf-pyridiniums into various 2-polyene sulfonylpyridines. This Zincke-like reaction involves the conversion of pyridines into electron-rich intermediates and subsequent regioselective electrophilic modification through the formation of an EDA complex, intermolecular single-electron transfer, radical coupling, and selective C2–N bond cleavage. In addition, the obtained 2-polyene sulfonylpyridine 2a displays interesting photophysical properties.

Fields of Study & Subjects

Radical Photochemical Reactions Sulfur-Based Synthesis Techniques Photopolymerization techniques and applications

Publication details

Journal / source
Organic Letters
Volume
28
Issue
8
Pages
2609–2614
Publication date
9 February 2026
Language
EN