Electrochemical Synthesis of 1,2-Substituted N -Amido Benzimidazoles by Reduction of Nitroarenes

Organic Letters 2026 Open access

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Authors: Daniel Doellerer, Aaron Schüll, Thomas Weyhermüller, Sebastian B. Beil, Siegfried R. Waldvogel
DOI: 10.1021/acs.orglett.5c05349
Cited by: 1
References: 46

Abstract

High Resolution Image Download MS PowerPoint Slide Despite the vast number of reports on benzimidazoles, 1,2-substituted N -amido benzimidazoles remain an underrepresented and scarcely accessible compound class with promising pharmacological relevance. We present a safe, reliable electrochemical protocol that provides easy access to those structures. The reaction exhibits broad functional group tolerance and affords the target compounds in ≤89% yields.

Fields of Study & Subjects

Radical Photochemical Reactions Nanomaterials for catalytic reactions Multicomponent Synthesis of Heterocycles

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
8
Pages
2591–2595
Publication date
16 February 2026
Language
EN