Discovery of Diverse Esterified seco -Polycyclic Polyprenylated Acylphloroglucinols from Two Species of Hypericum Linn. and Their Lipid-Lowering Effect

Organic Letters 2026

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Authors: Zhaoyue Dong, Yulu Xie, Kun Wu, Pingping Wang, Honghong Zhan, Lingjiang Zeng, Mohammad Mahmoud Nagdy, Fancheng Meng, Zhihua Liao, Dan Li, Min Chen
DOI: 10.1021/acs.orglett.5c05350
Cited by: 1
References: 23

Abstract

Hyperesternoids A–K ( 1–11, respectively), 11 unique esterified seco -PPAPs ( seco -polycyclic polyprenylated acylphloroglucinols) with three types of scaffold systems, 5/6 bicyclic ( 1–3 ), 5/7/6 tricyclic ( 4–6 ), and 5/6/6 tricyclic ( 7–11 ), were isolated from two plants of the Hypericum genus. Notably, crystalline mate and chemical transformation methods provided several practical strategies for the elucidation of seco -PPAPs with complex and variable structures. Biologically, the PPARα agonistic activities of all isolates were evaluated via the dual-luciferase reporter assay, and their lipid-lowering effects were studied.

Fields of Study & Subjects

Natural Compound Pharmacology Studies Bioactive natural compounds Phytochemistry and Biological Activities

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
6
Pages
2062–2068
Publication date
30 January 2026
Language
EN