Shimojilide, a Potent and Selective Antiproliferative Cyclic Lipopeptide from a Marine Cyanobacterium Okeania sp.

Organic Letters 2026

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Authors: Mizuho Niiyama, Naoaki Kurisawa, Shingo Dan, Kiyotake Suenaga
DOI: 10.1021/acs.orglett.5c05355
Cited by: 0
References: 29

Abstract

Shimojilide ( 1 ), a new cyclic lipopeptide, was isolated from a marine cyanobacterium Okeania sp. Its structure was elucidated by NMR and chemical derivatization, revealing a peptide–polyketide hybrid with a skipped diene and β-branched methyl group. Shimojilide ( 1 ) exhibited potent and selective antiproliferative activity with a unique JFCR39 fingerprint that poorly correlates with those of known anticancer agents, suggesting a distinct mechanism of action. Shimojilide ( 1 ) represents a promising lead for anticancer drug discovery.

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Marine Sponges and Natural Products Chemical Synthesis and Analysis

Publication details

Journal / source
Organic Letters
Volume
28
Issue
5
Pages
1810–1814
Publication date
27 January 2026
Language
EN