Asymmetric Cycloaddition of 1,6-Diynes with Alkenes Enabled by Ligand-to-Metal Chirality Transfer in Cobalt/Photoredox Cooperative Catalysis

Organic Letters 2026 Open access

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Authors: Takeshi Yasui, Keiji Yamada, Yuki Ishikawa, Kotoko Nakagawa, R. Fujii, Yoshihiko Yamamoto
DOI: 10.1021/acs.orglett.5c05365
Cited by: 1
References: 40

Abstract

Here we report a highly enantioselective cycloaddition of 1,6-diynes and alkenes mediated by cobalt/photoredox cooperative catalysis. This transformation requires a chiral monodentate phosphine ligand, which is rarely applied in such reactions because of its limited stereocontrol. DFT studies reveal that the ligand controls metal-centered chirality, enabling the synthesis of multisubstituted cyclohexadienes with excellent enantioselectivity.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic Alkyne Reactions Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
6
Pages
2076–2082
Publication date
29 January 2026
Language
EN