Photoredox-Lewis Acid Catalyst Enabled Decarboxylative Coupling of Carboxylic Acids with Aldehydes and Amines
Abstract
Photocatalysis has emerged as a promising strategy for unlocking novel reactivity from commercially accessible feedstocks. This work reports a three-component reaction of aldehydes, aliphatic secondary amines, and aliphatic carboxylic acids, enabled by a synergistic dual catalytic system merging photoredox and Lewis acid catalysis. This approach provides a modular route to access synthetically valuable α-branched tertiary amines in good yields.
Fields of Study & Subjects
Radical Photochemical Reactions
Asymmetric Hydrogenation and Catalysis
Chemical Synthesis and Reactions
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 5
- Pages
- 1797–1802
- Publication date
- 23 January 2026
- Language
- EN