Enantioselective Synthesis of Bicyclo[4.3.0]nonatrienones via Palladium-Catalyzed Desymmetric 1,5-Enyne Cycloisomerization

Organic Letters 2026

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Authors: Jiajun Lu, Hongyue Dong, Shu Sen Wu, Cheng Wang, Aijun Lin, Peng Sun
DOI: 10.1021/acs.orglett.5c05377
Cited by: 1
References: 64

Abstract

We herein disclose a palladium-catalyzed asymmetric desymmetric cycloisomerization of alkynyl-tethered cyclohexadienes, providing optically pure hydrindanes with one tertiary and one quaternary stereocenter. This reaction features a broad substrate scope, high atom economy, and good to excellent enantioselectivities. In addition, the diene and enone motifs embedded in the products offer synthetic handles for further structural diversification.

Fields of Study & Subjects

Catalytic Alkyne Reactions Catalytic C–H Functionalization Methods Synthetic Organic Chemistry Methods

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
5
Pages
1826–1831
Publication date
21 January 2026
Language
EN