Decoupling Radical Generation and Copper Catalysis for the Remote C–H Cyanation of Unfunctionalized Sulfonamides

Organic Letters 2026

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Authors: Jue Wang, Zhi Chen, Yali He, Chenxi Gu, Luwei Tong, Chaodong Wang, Jianjun Li
DOI: 10.1021/acs.orglett.5c05382
Cited by: 0
References: 82

Abstract

A decoupled photoredox/copper dual catalytic system for the remote C(sp 3 )–H cyanation of aliphatic sulfonamides is described. The strategy circumvents the need for substrate prefunctionalization, a limitation of previous “coupled” systems. An acridinium photocatalyst generates a nitrogen radical from a free N–H bond, while an independent copper cycle, sustained by an external oxidant, forges the C–CN bond with high δ-selectivity.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic C–H Functionalization Methods Synthesis and Catalytic Reactions

Publication details

Journal / source
Organic Letters
Volume
28
Issue
3
Pages
1109–1114
Publication date
13 January 2026
Language
EN