Divergent Access to α,β-Unsaturated Thiolated and Selenolated Lactams via a Unified Palladium-Catalyzed Carbonylative Transformation

Organic Letters 2026 Open access

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Authors: Zhiping Yin, Shuhui Sun, Xiaowen Qin, Heng Li, Fengxiang Zhu, Xiao-Feng Wu
DOI: 10.1021/acs.orglett.5c05383
Cited by: 1
References: 50

Abstract

Herein, a unified and divergent palladium-catalyzed carbonylative procedure for the direct synthesis of α,β-unsaturated thiolated and selenolated lactams is reported. This strategy enables the simultaneous construction of the lactam core and installation of valuable sulfur or selenium functionalities via a single catalytic operation. By employing simple propargylamine substrates together with diphenyl disulfide or diselenide under a carbon monoxide atmosphere, the corresponding lactams were formed in moderate to good yields with promising functional group tolerance.

Fields of Study & Subjects

Sulfur-Based Synthesis Techniques Organoselenium and organotellurium chemistry Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
5
Pages
1832–1837
Publication date
21 January 2026
Language
EN