Difluoromethylation of Arylsulfonium Salts with TMSCF 2 H
Abstract
H in DMF in the presence of CsF is achieved. The reaction proceeded smoothly at room temperature to furnish the corresponding difluoromethylated products in good yield with excellent selectivity through the formation and ligand coupling of sulfurane intermediates. This protocol represents the first catalyst-free difluoromethylation of arylsulfonium salts, exhibiting features distinct from those of previously reported metallophotocatalytic fluoroalkylation.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Catalytic C–H Functionalization Methods
Radical Photochemical Reactions
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 3
- Pages
- 1101–1108
- Publication date
- 7 January 2026
- Language
- EN