Total Synthesis of the Oligostilbenes Anigopreissin A and Fuliginosin A

Organic Letters 2026 Open access

Read full text
Authors: Aldahir Ramos Orea, Valeri Martínez-Barrita, Arturo Mejía-Galindo, Rubén O. Torres‐Ochoa
DOI: 10.1021/acs.orglett.5c05397
Cited by: 0
References: 26

Abstract

A convergent synthesis of the natural stilbenes anigopreissin A and fuliginosin A is presented. The key step involves a copper-catalyzed heteroannulation between an oxime acetate and a 4-substituted 1,3-cyclohexanedione, yielding a suitably substituted benzofuran-4-one via a mechanism that does not involve radicals. The use of methoxymethyl (MOM) ethers as protecting groups ensures the expedited completion of the sequence. The scope established for the heterocyclization suggests that this approach may be adapted to synthesize additional stilbenes.

Fields of Study & Subjects

Organic Chemistry Synthesis Methods Catalytic Alkyne Reactions Cyclization and Aryne Chemistry

Publication details

Journal / source
Organic Letters
Volume
28
Issue
22
Pages
6835–6840
Publication date
16 February 2026
Language
EN