Photocatalytic α-Selective σ-Bond Hydroboration of Bicyclo[1.1.0]butanes
Abstract
Cyclobutylboranes are important synthetic precursors for introducing strained cyclobutyl groups, yet their efficient synthesis remains a significant challenge. The recent development in photochemistry concerning bicyclo[1.1.0]butanes (BCBs, which are highly reactive radical acceptors) offers a direct route to access these motifs using boryl radicals. Herein, we report an effective and mild photomediated borylation of BCBs with high regioselectivity, enabling the synthesis of a series of cyclobutylborane compounds bearing diverse substituents. Comprehensive mechanistic studies provide strong evidence of a radical process involving hydrogen atom transfer (HAT).
Fields of Study & Subjects
Radical Photochemical Reactions
Organoboron and organosilicon chemistry
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 5
- Pages
- 1851–1856
- Publication date
- 23 January 2026
- Language
- EN