Direct Synthesis of Tricyclo[3.2.1.0 2,7 ]octenes via Palladium-Catalyzed Sequential Reactions of 2-Pyranones with 1,3-Dienes

Organic Letters 2026

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Authors: Jian-Bang Hu, Xin‐Lian Liu, Wenhua Gao, Jun Ying, Zhi Zhang, Jin‐Bao Peng
DOI: 10.1021/acs.orglett.5c05414
Cited by: 1
References: 42

Abstract

Given the widespread use of tricyclo[3.2.1.0 2,7 ]octene scaffolds in natural medicinal chemistry and biology, the development of methods for their synthesis remains important. Here, a palladium-catalyzed sequential [4 + 2]-cycloaddition/decarboxylation/intramolecular Diels–Alder reaction of 2-pyranones with 1,3-dienes is described for the direct access to valuable tricyclo[3.2.1.0 2,7 ]octenes with moderate to excellent yields and regioselectivities.

Fields of Study & Subjects

Catalytic Alkyne Reactions Oxidative Organic Chemistry Reactions Synthesis of Organic Compounds

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
5
Pages
1863–1868
Publication date
28 January 2026
Language
EN