Chlorjaponoids A and B, Two Lindenane–Guaiane Sesquiterpenoid Dimers with a Cage-like Tetracyclo[8.5.0.0 2,7 .0 3,13 ]pentadecane Scaffold from Chloranthus japonicus

Organic Letters 2026

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Authors: Lu Gan, Xinyi Hu, Rong Huang, Li-Fen Ma, Dean Guo, Wei Li
DOI: 10.1021/acs.orglett.5c05428
Cited by: 1
References: 25

Abstract

Two heterodimeric sesquiterpenoids, chlorjaponoids A ( 1 ) and B ( 2 ), were isolated from the whole plants of Chloranthus japonicus . Their structures, characterized by a unique cage-like tetracyclo[8.5.0.0 2,7 .0 3,13 ]pentadecane scaffold, were elucidated by comprehensive spectroscopic analysis and confirmed by single-crystal X-ray diffraction. Both compounds demonstrated antihepatic fibrosis activity in vitro.

Fields of Study & Subjects

Sesquiterpenes and Asteraceae Studies Natural Compound Pharmacology Studies Plant chemical constituents analysis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
6
Pages
2122–2125
Publication date
4 February 2026
Language
EN