Tandem Nitration-Cyclization-Rearrangement of Indole-Tethered 1,6-Enynes To Access NO 2 -Featured Heterocycles
Abstract
as the carbonyl oxygen source and low-cost TBN as the nitro reagent. Meanwhile, the stable indole skeleton could smoothly undergo rearrangement to access dicarbonyl fused cycles. In addition, complex molecular transformation and scaled-up experiments examined the application of this tandem system. Finally, diverse mechanistic studies (including isotopic labeling, radical inhibition/capturation experiments) explored the reaction pathway.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Synthesis and bioactivity of alkaloids
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 7
- Pages
- 2344–2348
- Publication date
- 7 February 2026
- Language
- EN