Fused and Spirocyclic Sulfones for Medicinal Chemistry via [3 + 2] Cycloaddition of Thiocarbonyl Ylide

Organic Letters 2026

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Authors: Tymofii V. Rudenko, Oleksandr Stepaniuk, Вадим М. Тимошенко, Andrey A. Tolmachev, Svitlana V. Shishkina, Pavel K. Mykhailiuk
DOI: 10.1021/acs.orglett.5c05431
Cited by: 0
References: 23

Abstract

The [3 + 2] cycloaddition between thiocarbonyl ylide CH 2 ═S (+) –CH 2 (−) and electron-deficient cyclic alkenes provides bicyclic sulfides. The reaction efficiently works on milligram, gram, and even multigram quantities. Standard modifications of the obtained products give fused and spirocyclic sulfones for medicinal chemistry.

Fields of Study & Subjects

Sulfur-Based Synthesis Techniques Synthesis and Reactivity of Sulfur-Containing Compounds Asymmetric Synthesis and Catalysis

Publication details

Journal / source
Organic Letters
Volume
28
Issue
4
Pages
1494–1498
Publication date
16 January 2026
Language
EN